Before you give it: is amoxicillin-clavulanate the right fit?
It is a strong, broad choice — but not right for every problem. A quick check first:
- Get a diagnosis first. Not every infection is bacterial or needs this combination; a vet should confirm what’s going on and whether it fits.
- Resistant and mixed infections are where it shines. The clavulanate overcomes the enzyme many resistant bacteria use against plain amoxicillin, so it covers infections amoxicillin alone would miss — but it is not an “any infection” cure-all.
- Weigh your pet. The dose is set by body weight, so your vet needs an accurate weight to prescribe correctly.
- Mention any prior reaction. Tell your vet about any prior reaction to penicillin, amoxicillin, or cephalexin — these are related drugs.
What amoxicillin-clavulanate for dogs and cats is
Amoxicillin-clavulanate is a penicillin-class antibiotic: amoxicillin combined with clavulanate, a beta-lactamase inhibitor.1 The clavulanate blocks the enzyme that many resistant bacteria use to break down amoxicillin, so the combination works against beta-lactamase-producing (penicillinase-producing) bacteria that plain amoxicillin cannot. Veterinarians prescribe it for susceptible infections — commonly skin and soft-tissue,2 dental, and urinary infections.3 It is a broad, well-characterized choice, but not right for every infection, which is why a veterinarian, not a website, decides whether it fits your pet.
We are a licensed veterinary pharmacy. We dispense what the vet prescribes4 — we do not diagnose or set doses — and we will tell you plainly when amoxicillin-clavulanate is not the right fit for your pet.
| Active ingredient | Amoxicillin + clavulanate (potassium clavulanate) |
|---|---|
| Strength | 375, 625, or 1000 mg combined total per tablet |
| Also sold as | Clavamox, Augmentin |
| Drug class | Aminopenicillin + beta-lactamase inhibitor |
| Form | Tablets in blister packs |
| Intended use | Dogs and cats only |
| Availability | Prescription, not for human use |
| Delivery to | All 50 US states, contact us for other countries |
Amoxicillin-clavulanate dosing for dogs and cats: your vet sets it
Amoxicillin-clavulanate for dogs and cats is dosed by body weight and set by your prescribing veterinarian, who chooses the dose based on what is being treated, your pet’s weight, and their history. We do not set doses, and this page does not list one. The label on your order reflects your prescribing vet’s instructions — follow it exactly and never adjust the dose yourself. It comes in 375, 625, and 1000 mg tablets (combined amoxicillin + clavulanate); which strength fits your pet is part of what the vet decides.
Side effects to watch for
Most dogs and cats tolerate it well. The most common effects are mild digestive upset — vomiting, diarrhea, or reduced appetite. The important one is an allergic reaction: hives, facial swelling, or difficulty breathing are an emergency — stop the medication and contact a veterinarian immediately. Tell your vet about any prior reaction to penicillin, amoxicillin, or cephalexin, because these are related drugs.
⚠ Important safety notes
- Prescription medication. A veterinarian decides whether it’s appropriate and sets the dose — we never set one.
- Give it with food. This often eases the common digestive effects (vomiting, diarrhea, appetite loss).
- Allergic reaction is an emergency. Hives, facial swelling, or difficulty breathing — stop and contact a vet immediately.
- Penicillin family. Mention any prior penicillin, amoxicillin, or cephalexin reaction. For dogs and cats only; never dose a pet from a human or another species’ prescription.
Cost & how to get it
There is no public cart or online payment step. You place a reservation, a veterinarian reviews it and writes the prescription if it’s appropriate, then our pharmacy sends a secure payment link before anything ships — so the veterinary review costs you nothing separate, and you pay only for the medication. If amoxicillin-clavulanate isn’t right for your dog or cat, the order isn’t filled and you aren’t charged.
| Pack size | 375 mg | 625 mg | 1000 mg |
|---|---|---|---|
| 30 tablets | $49.99 · $1.67/tablet | $59.99 · $2.00/tablet | $69.99 · $2.33/tablet |
| 90 tablets MOST POPULAR | $104.99 · $1.17/tablet | $124.99 · $1.39/tablet | $144.99 · $1.61/tablet |
| 200 tablets | $184.99 · $0.92/tablet | $214.99 · $1.07/tablet | $249.99 · $1.25/tablet |
| 500 tablets BEST VALUE | $339.99 · $0.68/tablet | $389.99 · $0.78/tablet | $439.99 · $0.88/tablet |
Higher strengths cost a little more at each pack size — your vet sets the strength and course your pet needs.
Related guides
Frequently asked questions
Do I need a prescription?
Yes — but you don’t have to arrange it yourself. A veterinarian reviews your order and prescribes it, then we dispense it legally. If it’s not right for your dog or cat, the order isn’t filled and you aren’t charged.
What is amoxicillin-clavulanate used for in dogs and cats?
It is a penicillin-class antibiotic (amoxicillin plus clavulanate) prescribed for skin, soft-tissue, dental, and urinary infections, including ones caused by resistant bacteria plain amoxicillin can’t beat. Whether it fits your pet is the prescribing vet’s decision.
What dose should I give?
We don’t provide dosing. The correct dose depends on your pet’s weight and condition and is set by the prescribing veterinarian. Follow the prescription exactly.
What do 375, 625, and 1000 mg mean?
Those are the combined amoxicillin + clavulanate amounts per tablet (for example, 375 mg = 250 mg amoxicillin + 125 mg clavulanate). Which strength suits your pet is part of what the prescribing vet decides.
Do I get exactly what I see on this site?
We can’t guarantee a specific manufacturer. What you receive may look different, but the drug, strength, and ingredients are the same.
Medical disclaimer
This site is for informational purposes only and is not veterinary advice, diagnosis, or a treatment recommendation. A licensed veterinarian should determine medication selection, prescribing, dosing, and treatment for the individual animal. Never give a dog or cat antibiotics intended for another species; the wrong drug or dose can seriously harm your pet. All medications sold on this site are for animal use only and are not intended for human use or consumption.
Sources & References
- Merck Veterinary Manual, “Penicillins Use in Animals” (beta-lactamase-protected penicillins). merckvetmanual.com (accessed 2026) Supports: clavulanate is a beta-lactamase inhibitor that, combined with amoxicillin, extends the spectrum against beta-lactamase-producing bacteria.
- Hillier A, Lloyd DH, Weese JS, et al. “Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (ISCAID).” Vet Dermatol 2014;25(3):163–175. doi:10.1111/vde.12118. doi.org (2014) Supports: amoxicillin-clavulanate is a first-line systemic option for canine superficial bacterial folliculitis (pyoderma).
- Weese JS, Blondeau J, Boothe D, et al. “ISCAID guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats.” Vet J 2019;247:8–25. doi:10.1016/j.tvjl.2019.02.008; PMID 30971357. doi.org (2019) Supports: amoxicillin-clavulanate is a top empirical choice for sporadic bacterial cystitis (UTI) in dogs.
- FDA Center for Veterinary Medicine. Animal & Veterinary. fda.gov (accessed 2026) Supports: the prescription status of veterinary antibiotics.
